An improved method for quantitative trait loci detection and identification of within-line segregation in F2 intercross designs
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An improved method for quantitative trait loci detection and identification of within-line segregation in F2 intercross designs.
We present a new flexible, simple, and powerful genome-scan method (flexible intercross analysis, FIA) for detecting quantitative trait loci (QTL) in experimental line crosses. The method is based on a pure random-effects model that simultaneously models between- and within-line QTL variation for single as well as epistatic QTL. It utilizes the score statistic and thereby facilitates computatio...
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